Selected Publications:
- Marisa C Hamilton, James D Fife, Ersin Akinci, Tian Yu, Benyapa Khowpinitchai, Minsun Cha, Sammy Barkal, Thi Tun Thi, Grace Yeo, Juan Pablo Ramos Barroso, Matthew Jake Francoeur, Minja Velimirovic, David K Gifford, Guillaume Lettre, Haojie Yu#, Christopher A Cassa#, Richard I Sherwood# (Co-corresponding author) (2023). Systematic elucidation of genetic mechanisms underlying cholesterol uptake. Cell Genomics. In Press (#, corresponding author)
- Karamanavi, E., McVey, D. G., van der Laan, S. W., Stanczyk, P. J., Morris, G. E., Wang, Y., Yang, W., Chan, K., Poston, R. N., Luo, J., Zhou, X., Gong, P., Jones, P. D., Cao, J., Kostogrys, R. B., Webb, T. R., Pasterkamp, G., Yu, H., Xiao, Q., Greer, P. A., … Ye, S. (2022). The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis. Circulation research, 131(12), 1004–1017.
- Rimbert, A., Yeung, M. W., Dalila, N., Thio, C. H. L., Yu, H., Loaiza, N., Oldoni, F., van der Graaf, A., Wang, S., Said, M. A., Blauw, L. L., Girardeau, A., Bray, L., Caillaud, A., Bloks, V. W., Marrec, M., Moulin, P., Rensen, P. C. N., van de Sluis, B., Snieder, H., … Kuivenhoven, J. A. (2022). Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile. Arteriosclerosis, thrombosis, and vascular biology, 42(10), 1262–1271.
- Yu, H. (2021). The Ongoing Efforts Toward a Definite Diagnosis of Familial Hypercholesterolemia. JACC: Asia 1, 90-92.
- Yu, H. (2021). Atherosclerotic Plaque Regression: Experimental Approaches and Therapeutic Advances. Trends Cell Biol 31, 424-427.
Before starting my independent lab at NUS
- Friesen, M.*, Warren, C.R.*, Yu, H.*, Toyohara, T.*, Ding, Q., Florido, M.H.C., Sayre, C., Pope, B.D., Goff, L.A., Rinn, J.L., et al. (2020). Mitoregulin Controls beta-Oxidation in Human and Mouse Adipocytes. Stem Cell Reports 14, 590-602. (*, equal contribution)
- Chen, Z., Yu, H., Shi, X., Warren, C.R., Lotta, L.A., Friesen, M., Meissner, T.B., Langenberg, C., Wabitsch, M., Wareham, N., et al. (2020). Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes. Circ Res 126, 330-346.
- Toyohara, T., Roudnicky, F., Florido, M.H.C., Nakano, T., Yu, H., Katsuki, S., Lee, M., Meissner, T., Friesen, M., Davidow, L.S., et al. (2020). Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell 27, 178-180.
- Yu, H.#, Rimbert, A., Palmer, A.E., Toyohara, T., Xia, Y., Xia, F., Ferreira, L.M.R., Chen, Z., Chen, T., Loaiza, N., et al. (2019). GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. Cell 179, 1276-1288 e1214. (#, corresponding author)
- Xu, Y.X., Redon, V., Yu, H., Querbes, W., Pirruccello, J., Liebow, A., Deik, A., Trindade, K., Wang, X., Musunuru, K., et al. (2018). Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol. Atherosclerosis 268, 196-206.
- Liu, D.J.*, Peloso, G.M.*, Yu, H.*, Butterworth, A.S.*, Wang, X.*, Mahajan, A.*, Saleheen, D., Emdin, C.*, Alam, D., Alves, A.C., et al. (2017). Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet 49, 1758-1766. (*, equal contribution)
- Yu, H., and Cowan, C.A. (2016). Minireview: Genome Editing of Human Pluripotent Stem Cells for Modeling Metabolic Disease. Mol Endocrinol 30, 575-586.
- Peter, S., Yu, H., Ivanyi-Nagy, R. & Droge, P. Cell-based high-throughput compound screening reveals functional interaction between oncofetal HMGA2 and topoisomerase I. Nucleic Acids Res 44, e162, doi:10.1093/nar/gkw759 (2016).
- Yu, H., and Droge, P.. Replication-induced supercoiling: a neglected DNA transaction regulator?. Trends Biochem Sci, 39(5):219-20 (2014). PMID: 24637041
- Yu, H., Lim, H.H., Tjokro, N.O., Sathiyanathan, P., Natarajan, S., Chew, T.W., Klonisch, T., Goodman, S.D., Surana, U., and Droge, P. (2014). Chaperoning HMGA2 protein protects stalled replication forks in stem and cancer cells. Cell Rep 6, 684-697.
- Adhireksan, Z., Davey, G.E., Campomanes, P., Groessl, M., Clavel, C.M., Yu, H., Nazarov,A.A., Yeo, C.H., Ang, W.H., Droge, P., et al. Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity. Nat Commun 5, 3462 (2014).
- Yan, X., Yu, H., Hong, Q., and Li, S.P. Cre/lox system and PCR-based genome engineering in Bacillus subtilis. Appl Environ Microbiol 74, 5556-5562 (2008). PMCID:PMC2546623
- Yu, H., Yan, X., Shen, W., Hong, Q., Zhang, J., Shen, Y., and Li, S. Expression of methyl parathion hydrolase in Pichia pastoris. Curr Microbiol 59, 573-578 (2009). PMID: 19802642
- Shen, Y.J., Lu, P., Mei, H., Yu, H., Hong, Q., and Li, S.P. Isolation of a methyl parathion-degrading strain Stenotrophomonas sp. SMSP-1 and cloning of the ophc2 gene. Biodegradation 21, 785-792 (2010).
- Yu, H., Yan, X., Shen, W., Shen, Y., Zhang, J., and Li, S. Efficient and precise construction of markerless manipulations in the Bacillus subtilis genome. J Microbiol Biotechnol 20, 45-53 (2010).